IMMUNOLOGY

Detailed explanation-1: -Collectively, such data suggest that NGF and other neurotrophins play a role in sleep. Other cytokines that may also be involved in the regulation of sleep include; IL2, IL6, IL8, IL15, IL18, EGF, acidic fibroblast growth factor, colony stimulating factor, and interferons (Table 1; [reviewed 2, 3]).

Detailed explanation-2: -Cytokines are small proteins that are crucial in controlling the growth and activity of other immune system cells and blood cells. When released, they signal the immune system to do its job. Cytokines affect the growth of all blood cells and other cells that help the body’s immune and inflammation responses.

Detailed explanation-3: -Healthy sleep can help boost the immune system and can even help to prevent you from getting sick as often. Sleep not only increases your immune system function. It’s also been shown to play a role in improving antibody responses to vaccinations.

Detailed explanation-4: -As we have reviewed, sleep is altered during infection. Infection increases the concentrations of cytokines, including IL-1, and the release of neurotransmitters, including 5-HT, in the brain, and interactions between IL-1 and 5-HT contribute to the regulation of sleep.