IMMUNOLOGY

Detailed explanation-1: -HIV binds to the CD4 molecule on the surface of helper T-cells and replicates within them. This results in destruction of CD4+ T-cells and leads to a steady decline in this population of T-cells.

Detailed explanation-2: -Human immunodeficiency virus (HIV) HIV targets CD4+ T cells by binding to the CD4 molecule on the cell surface, as well as a chemokine coreceptor – usually CCR5 or CXCR4.

Detailed explanation-3: -HIV destroys CD4 T lymphocytes (helper T cells). Because of this, healthcare professionals measure CD4 levels to monitor HIV progression and AIDS. Helper T cells are crucial for immune system function and activate after encountering antigens from disease-causing microorganisms.

Detailed explanation-4: -Human Immunodeficiency Virus (HIV) specifically attacks Helper T cells. Without an adequate supply of Helper T cells, the immune system cannot signal B cells to produce antibodies or Cytotoxic T cells to kill infected cells.

Detailed explanation-5: -Evidence suggests that CD8+ T cells are involved in the control of virus replication during HIV and SIV infections. During early HIV infection, the cytolytic activity of CD8+ T cells is responsible for control of viremia.

Detailed explanation-6: -Role of CD4 T Cells in HIV Infection CD4 cells are the prime targets for this function in the course of an infection. During infection, HIV attaches to these helper cells, emptying its genetic material within so that the host’s genetic coding can be altered to produce other HIV virions (complete virus particles).