IMMUNOLOGY

Detailed explanation-1: -This histamine is released from these cells by the stimuli inducing acute inflammation, anaphylatoxins, and histamine releasing factors. Histamine increases the vasodilatation, and also increases the vascular permeability in the immediate transient phase of the acute inflammatory reaction.

Detailed explanation-2: -The message is, “Release histamines, ‘’ which are stored in the mast cells. When they leave the mast cells, histamines boost blood flow in the area of your body the allergen affected. This causes inflammation, which lets other chemicals from your immune system step in to do repair work.

Detailed explanation-3: -Mast cells respond to IL-33 released during cell injury by initiating a pro-inflammatory response. During cell injury, for instance induced by mechanical trauma, structural cell types such as epithelial cells release IL-33.

Detailed explanation-4: -In response to tissue injury, the body initiates a chemical signaling cascade that stimulates responses aimed at healing affected tissues. These signals activate leukocyte chemotaxis from the general circulation to sites of damage. These activated leukocytes produce cytokines that induce inflammatory responses [7].

Detailed explanation-5: -Histamine contributes to the progression of allergic-inflammatory responses by enhancement of the secretion of pro-inflammatory cytokines, such as IL-1, IL-1, and IL-6, as well as chemokines like RANTES or IL-8, both in several cell types and in local tissues (Fig 1).

Detailed explanation-6: -Mast cell degranulation most likely evolved to combat parasites, and so induces coughing, sneezing, tearing of the eyes, scratching of the skin, and/or cramping of the gut and diarrhea, all of which are designed to expel these types of pathogens.

Detailed explanation-7: -Mast cells are key players in the inflammatory response as they can be activated to release a wide variety of inflammatory mediators, by many different antigens including allergens, pathogens and physiological mediators.