IMMUNOLOGY

OVERVIEW OF THE IMMUNE SYSTEM

THE GOOD BAD AND UGLY OF THE IMMUNE SYSTEM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the main advantage of live attenuated vaccine?
A
It provides more durable immunity; boosters may be required, though less frequently than would otherwise be necessary.
B
It is safer than other kinds of vaccines.
C
It does not cause any severe side effects or complications.
D
It is suitable for people with any type of health.
Explanation: 

Detailed explanation-1: -Live-attenuated vaccines Because these vaccines are so similar to the natural infection that they help prevent, they create a strong and long-lasting immune response. Just 1 or 2 doses of most live vaccines can give you a lifetime of protection against a germ and the disease it causes.

Detailed explanation-2: -These vaccines contrast to those produced by “killing” the virus (inactivated vaccine). Attenuated vaccines stimulate a strong and effective immune response that is long-lasting. In comparison to inactivated vaccines, attenuated vaccines produce a stronger and more durable immune response with a quick immunity onset.

Detailed explanation-3: -Live vaccines generate a strong immune response because they mimic natural infection. They stimulate both the humoral and cellular immune responses, leading to high-affinity antibodies and long-term immune memory. Live vaccines can sometimes cause a weakened disease pattern in a small proportion of vaccine recipients.

Detailed explanation-4: -What are the advantages of Attenuated Vaccines? One dose is sufficient for long lasting immunity. Because it is a vaccine with a weakened pathogen it will still multiply in the body while increasing the exposure to the immune system. Also infection can spread to non-vaccinated people conferring immunity.

Detailed explanation-5: -Live attenuated vaccines contain whole bacteria or viruses which have been “weakened”(attenuated) so that they create a protective immune response but do not cause disease in healthy people.

Detailed explanation-6: -The immune response to a live, attenuated vaccine is virtually identical to that produced by a natural infection because the immune system does not differentiate between an infection with a weakened vaccine virus and an infection with a wild NOTES Page 5 Principles of Vaccination 5 1 virus.

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