IMMUNOLOGY

Detailed explanation-1: -Failure or breakdown of immunological tolerance results in autoimmunity and autoimmune diseases. Such events are related to both genetic and environmental factors, the latter being mainly represented by infections.

Detailed explanation-2: -Loss of tolerance results in autoimmune disorders, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes (T1D) and primary biliary cirrhosis (PBC).

Detailed explanation-3: -Tolerance fails because of the interaction of a wrong environment with the wrong genes, resulting in autoimmune disease. Options for treatment will increasingly include new selective immunotherapies in place of present global immunosuppression. Components of immune (and autoimmune) responses.

Detailed explanation-4: -The ability to discriminate between self and nonself antigens is vital to the functioning of the immune system as a specific defense against invading microorganisms. Failure of the immune system to “tolerate” self tissues can result in pathological autoimmune states leading to debilitating illness and sometimes death.

Detailed explanation-5: -Immune tolerance therapies are designed to stop, or even prevent, the autoimmune disease while leaving the body’s disease-fighting abilities intact. These tolerance therapies essentially reprogram the immune system, so that a short course of treatment will have long-lasting, perhaps lifelong effects.

Detailed explanation-6: -If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often.

Detailed explanation-7: -Common ones include lupus, rheumatoid arthritis, Crohn’s disease and ulcerative colitis. Autoimmune diseases can affect many types of tissues and nearly any organ in your body.