IMMUNOLOGY

Detailed explanation-1: -NK cells are best known for killing virally infected cells, and detecting and controlling early signs of cancer.

Detailed explanation-2: -Natural killer (NK) cells target and kill aberrant cells, such as virally infected and tumorigenic cells. Killing is mediated by cytotoxic molecules which are stored within secretory lysosomes, a specialized exocytic organelle found in NK cells.

Detailed explanation-3: -Natural killer (NK) cells are lymphocytes of the innate immune system that participate in early defense against foreign cells and autologous cells undergoing various forms of stress, such as microbial infection or tumour transformation [1, 2].

Detailed explanation-4: -NK cells can kill virally infected of transformed cells via the directed release of lytic granules or by inducing death receptor-mediated apoptosis via the expression of Fas ligand or TRAIL.

Detailed explanation-5: -Natural killer (NK) cells are innate lymphocytes that represent the first line of defense against tumor cells and viral infections [1, 2].

Detailed explanation-6: -The innate immune system is the body’s first line of defense against germs entering the body. It responds in the same way to all germs and foreign substances, which is why it is sometimes referred to as the “nonspecific” immune system.

Detailed explanation-7: -This review focuses on the role of NK cells in immunodefense against infections. Natural killer cells are cytotoxic lymphocytes that are able to kill target cells expressing PAMPs or DAMPs as a consequence of infection or cellular transformation.