MICROANATOMY

Detailed explanation-1: -Definition. Hemostasis is the mechanism that leads to cessation of bleeding from a blood vessel. It is a process that involves multiple interlinked steps. This cascade culminates into the formation of a “plug” that closes up the damaged site of the blood vessel controlling the bleeding.

Detailed explanation-2: -The stoppage of bleeding is known as hemostasis. When blood vessels are damaged, this vital process helps to limit or prevent blood loss. It involves several steps, including blood vessel spasms, the formation of a platelet plug, and coagulation of the blood.

Detailed explanation-3: -Hemostasis may be categorized into primary (platelet plug formation), secondary (formation of a stabilized fibrin clot through the coagulation cascade), and tertiary (formation of plasmin for breakdown of fibrin via fibrinolysis) concurrent processes.

Detailed explanation-4: -A bleeding time evaluation is used to measure the primary phase of hemostasis, which involves platelet adherence to injured capillaries and then platelet activation and aggregation. The bleeding time can be abnormal when the platelet count is low or the platelets are dysfunctional.

Detailed explanation-5: -Hereditary bleeding disorders occur due to the absence or deficiency of specific clotting proteins. The three most common hereditary bleeding disorders are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency) and von Willebrand disease.