MICROANATOMY

Detailed explanation-1: -Chemotaxis is the directed migration of a cell in response to a chemical stimulus, such as a growth factor. The specific ligands and receptors used in chemotaxis vary among cell types, as do the specific mechanisms used to relay chemotactic signals.

Detailed explanation-2: -Leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection.

Detailed explanation-3: -The chemicals that trigger an inflammatory response attract leukocytes to the site of injury or infection.

Detailed explanation-4: -Transendothelial migration (TEM), the step in the inflammatory response in which leukocytes actually cross the endothelial cells lining the blood vessels at the site of inflammation, is a critical point in the regulation of this response.