MICROANATOMY

Detailed explanation-1: -Basophils contain anticoagulant heparin, which prevents blood from clotting too quickly. They also contain the vasodilator histamine, which promotes blood flow to tissues. They can be found in unusually high numbers at sites of ectoparasite infection, e.g., ticks.

Detailed explanation-2: -Basophils play crucial roles in both IgE-dependent and-independent allergic inflammation, through their migration to the site of inflammation and secretion of various mediators, including cytokines, chemokines, and proteases.

Detailed explanation-3: -Neutrophils comprise 50% to 70% of circulating leukocytes and represent the body’s initial line of defense. They are involved in the acute inflammatory response to bacterial infection and removal of the bacteria by phagocytosis. They are also the most numerous cells to arrive at the site of injury or infection.

Detailed explanation-4: -During allergic reactions, basophils release two enzymes, histamine and heparin. Histamine enlarges your blood vessels to improve blood flow and heal the affected area. Histamine opens pathways for other cells in your immune system to quickly target and respond to the allergen.