MICROANATOMY

Detailed explanation-1: -In the case of T cells, development is compartmentalized, with different types of stromal cells in the thymic cortex and medulla. Most steps in T-cell differentiation occur in the cortex of the thymus. The thymic medulla contains mainly mature T cells.

Detailed explanation-2: -T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells.

Detailed explanation-3: -The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 / T cells, / T cells, NKT cells, Treg, and IEL all develop in and must leave the thymus to provide their functions elsewhere in the body.