MICROANATOMY

ENDOCRINE ORGANS AND RESPIRATORY SYSTEM

PARATHYROID

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Causes of hypoparathyroidism include
A
autoimmune
B
Surgically induced
C
DiGeorge syndrome
D
Chronic renal failure
Explanation: 

Detailed explanation-1: -What causes hypoparathyroidism? In some situations, hypoparathyroidism is present from birth (congenital), such as occurs with DiGeorge syndrome and other rare inherited conditions (see next section). In others, hypoparathyroidism develops later in life as an acquired condition.

Detailed explanation-2: -Thus, children with the DiGeorge syndrome may be at higher risk for hypothyroidism. Because of this potential association, patients who are considered to have this anomaly should have early newborn thyroid screening.

Detailed explanation-3: -Children with complete DiGeorge syndrome are born without a thymus and are therefore profoundly deficient in T cells and extremely susceptible to infections. Without treatment, the disorder is usually fatal by two or three years of age.

Detailed explanation-4: -Causes of hypoparathyroidism being born without parathyroid glands or with glands that don’t work properly – for example, people with the inherited genetic disorder DiGeorge syndrome can have underdeveloped parathyroid glands. radiotherapy to treat throat or neck cancer.

Detailed explanation-5: -22q11 deletion syndrome (22q11DS), also known as DiGeorge syndrome or velocardiofacial syndrome, is the most common human genetic microdeletion. Hypocalcemia secondary to hypoparathyroidism is a common finding in this condition and may present with seizures.

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