MICROANATOMY

Detailed explanation-1: -Chronic kidney failure is the most common cause of secondary hyperparathyroidism. In some people with long-term secondary hyperparathyroidism, usually from end-stage kidney disease, the parathyroid glands enlarge. They begin to release parathyroid hormone on their own.

Detailed explanation-2: -Primary hyperparathyroidism occurs when one or more of the parathyroid glands makes too much parathyroid hormone, usually because of a non-cancerous tumor. Secondary hyperparathyroidism occurs when there is an increase in PTH production due to abnormalities in all the parathyroid glands and cells.

Detailed explanation-3: -Secondary hyperparathyroidism is common among patients with vitamin D deficiency and chronic kidney disease. Since about half of the world population is vitamin D deficient, and about 1/7 have CKD, it is important to understand the condition in depth.

Detailed explanation-4: -What is secondary hyperparathyroidism? Secondary hyperparathyroidism occurs when the parathyroid glands become enlarged and release too much PTH, causing a high blood level of PTH. There are several reasons why this happens in patients with kidney disease: Higher blood phosphorus levels.