MICROANATOMY

Detailed explanation-1: -During a sestamibi scan, the body absorbs a radioactive agent that travels to an overactive parathyroid gland, and a doctor can use single photon emission computed tomography (SPECT) scans to produce 3D images of the parathyroid glands & other neck structures.

Detailed explanation-2: -A parathyroid MIBI scan is used in nuclear medicine to look at possible problems involving the parathyroid gland(s). The parathyroid scan uses the radioisotope, technetium-99m sestamibi (or MIBI), which is injected into the body and absorbed by the overactive parathyroid mitochondria.

Detailed explanation-3: -Mechanism of Action Sestamibi is characterized as lipophilic and cationic. It is also characterized as a transport substrate for multidrug resistance-related protein-1 and P-glycoprotein. [9] It has a predilection for tissues that demonstrate both high mitochondrial content and negative plasma membrane potentials.

Detailed explanation-4: -It takes approximately two hours to perform the Sestamibi scan after it has been injected. Pictures of the neck and chest are usually taken immediately after the injection and again in 1.75 to 2.0 hours (shown above).