MICROANATOMY

Detailed explanation-1: -The process by which a cartilage intermediate is formed and replaced by bone cells is called endochondral ossification.

Detailed explanation-2: -Bone formation requires a template for development. This template is mostly cartilage, derived from embryonic mesoderm, but also includes undifferentiated mesenchyme (fibrous membranes) in the case of intramembranous ossification. This framework determines where the bones will develop.

Detailed explanation-3: -Intramembranous ossification is the process of bone development from fibrous membranes. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles. Ossification begins as mesenchymal cells form a template of the future bone.

Detailed explanation-4: -Endochondral ossification is the mechanism responsible for the formation of all long bones of the axial skeleton (vertebrae and ribs) and the appendicular skeleton (limbs).

Detailed explanation-5: -The process of bone formation is called osteogenesis or ossification. After progenitor cells form osteoblastic lines, they proceed with three stages of development of cell differentiation, called proliferation, maturation of matrix, and mineralization.