PATHOLOGY

Detailed explanation-1: -During anaphase, sister chromatids are separated at the centromere and are pulled towards opposite poles of the cell by the mitotic spindle . During telophase, chromosomes arrive at opposite poles and unwind (uncoil) into thin strands of DNA, the spindle fibers disappear, and the nuclear membrane reappears.

Detailed explanation-2: -Summary: DNA uncoils from the nucleosome asymmetrically (uncoiling from one end much more easily) scientists have discovered. The DNA is packaged into chromosomes, which resemble beaded bracelets. The string of DNA is coiled around beads, called histones, to create nucleosomes.

Detailed explanation-3: -A chromatid is one of the two identical halves of a chromosome that has been replicated in preparation for cell division. The two “sister” chromatids are joined at a constricted region of the chromosome called the centromere.

Detailed explanation-4: -Figure 1: Chromosomes are composed of DNA tightly-wound around histones. Chromosomal DNA is packaged inside microscopic nuclei with the help of histones. These are positively-charged proteins that strongly adhere to negatively-charged DNA and form complexes called nucleosomes.

Detailed explanation-5: -Following cell division, the separated chromatids uncoil; the loosely coiled DNA, wrapped around its associated proteins (histones) to form beaded structures called nucleosomes, is termed chromatin.