PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The mutation occurred in somatic cells.
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The mutation occurred in gametic cells.
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The mutation is recessive.
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The mutation is sex-linked.
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Detailed explanation-1: -Which statement best explains why people with cancer due to asbestos exposure do not pass the mutation on to their offspring? The mutation occurred in somatic cells.
Detailed explanation-2: -Exposure to asbestos causes most mesotheliomas (a relatively rare cancer of the thin membranes that line the chest and abdomen); it can also cause cancers of the lung, larynx, and ovary.
Detailed explanation-3: -A person born with a mutated BAP1 gene has more risk of developing mesothelioma. Asbestos exposure is the leading cause of mesothelioma. The BAP1 gene mutation can also develop later in life as cells become malignant. Asbestos exposure increases mesothelioma risk in someone with a BAP1 gene mutation.
Detailed explanation-4: -Sickle cell disease (SCD) is a genetic disorder caused by a mutation in both copies of a person’s HBB gene. This gene encodes a component of hemoglobin, the oxygen-carrying protein in red blood cells. The mutation causes hemoglobin molecules to stick together, creating sickle-shaped red blood cells.