PATHOLOGY

Detailed explanation-1: -Wound healing is classically divided into 4 stages: (A) hemostasis, (B) inflammation, (C) proliferation, and (D) remodeling. Each stage is characterized by key molecular and cellular events and is coordinated by a host of secreted factors that are recognized and released by the cells of the wounding response.

Detailed explanation-2: -During the inflammatory phase, damaged cells, pathogens, and bacteria are removed from the wound area. These white blood cells, growth factors, nutrients and enzymes create the swelling, heat, pain and redness commonly seen during this stage of wound healing.

Detailed explanation-3: -The Vascular Response: Hemostasis and Coagulation Sometimes this phase is also described as the ‘lag-phase’, in which the organism has to manage the recruitment of the many cells and factors for the healing process in the absence of the mechanical strength of the wound [1] .

Detailed explanation-4: -Inflammatory phase – This phase begins at the time of injury and lasts up to four days. Proliferative phase – This phase begins about three days after injury and overlaps with the inflammatory phase. Remodeling phase – This phase can continue for six months to one year after injury.