IMMUNOLOGY

Detailed explanation-1: -The small site on an antigen to which a complementary antibody may specifically bind is called an epitope or antigenic determinant. This is usually one to six monosaccharides or five to eight amino acid residues on the surface of the antigen.

Detailed explanation-2: -T cell epitopes are usually protein antigen-derived peptides presented by MHC molecules on antigen-presenting cells and recognized by T-cell receptors. B cell epitopes are either peptides or protein surface residues that bind to an antibody.

Detailed explanation-3: -X-ray co-crystallography and cryogenic electron microscopy (cryo-EM). Array-based oligo-peptide scanning. Site-directed mutagenesis mapping. High-throughput shotgun mutagenesis epitope mapping. Hydrogen–deuterium exchange (HDX). More items