ANTIGENS
ANTIGENS AND IMMUNOGENICITY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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All cells express class I MHC molecule
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exogenous antigens are processed by endocytic pathway
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class III MHC genes encode membrane bound proteins
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MHC molecules are lipoproteins
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Detailed explanation-1: -Exogenous proteins, however, are primarily presented by MHC-II molecules. Antigens are internalized by several pathways, including phagocytosis, macropinocytosis, and endocytosis, and eventually traffic to a mature or late endosomal compartment where they are processed and loaded onto MHC-II molecules.
Detailed explanation-2: -Once an antigen is internalized, it is degraded into peptides within compartments of endocytic processing pathway. The endocytic pathway appears to involve three increasingly acidic compartments, early endosomes (pH 6-6.5), late endosomes or endo-lysosome (pH 5-6) and lysosomes (pH 4.5-5).
Detailed explanation-3: -Antigen-presenting cells are involved in both the innate and adaptive immune responses. Macrophages and B cells ingest antigens by different mechanisms, but both cells process antigen using the endocytic pathway.