IMMUNOLOGY

Detailed explanation-1: -IgG has four subclasses, named IgG1, IgG2, IgG3, and IgG4 [25]. Although all the subclasses have more than 90% identity on the amino acid level, each subclass however has a unique profile with respect to the length of hinge region, the number of inter-chain disulfide bonds, and Fc-effector functions.

Detailed explanation-2: -The IgG class of antibodies is composed of four different subtypes of IgG molecules called the IgG subclasses. These are designated IgG1, IgG2, IgG3 and IgG4. Patients with persistently low levels of one or two IgG subclasses and a normal total IgG level have a selective IgG subclass deficiency.

Detailed explanation-3: -Clinical Significance. Immunoglobulin G Subclass 3-IgG 3 deficiencies are found in a small percentage of individuals with recurrent infections. Increased levels are found in diseases such as Kawasaki’s Disease, Primary Biliary Cirrhosis, Hepatitis B, Secondary Syphilis and Borreliosis.