ANTIGENS
T LYMPHOCYTES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Define class I MHC
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defines self on all nucleated cells, presentation of extracellular pathogens
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defines self on some nucleated cells, presentation of extracellular pathogens
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mostly restricted to pAPCs, presentation of extracellular pathogens
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None of the above
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Explanation:
Detailed explanation-1: -MHC I molecules are expressed on all nucleated cells and are essential for presentation of normal “self” antigens. Cells that become infected by intracellular pathogens can present foreign antigens on MHC I as well, marking the infected cell for destruction.
Detailed explanation-2: -Class I MHC proteins are expressed on virtually all nucleated cells. This is presumably because effector cytotoxic T cells must be able to focus on and kill any cell in the body that happens to become infected with an intracellular microbe such as a virus.
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