HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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How are early responses mediated?
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mast cell granule release of histamine, leukotrienes, and prostaglandins
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cytokines released from the mast cells increase expression of chemokines and CAMs on endothelium facilitating influx of neutrophils, eosinophils, and TH2 cells. Eosinophils play a large role in recruiting neutrophils and degranulation
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -Mast cell degranulation most likely evolved to combat parasites, and so induces coughing, sneezing, tearing of the eyes, scratching of the skin, and/or cramping of the gut and diarrhea, all of which are designed to expel these types of pathogens.
Detailed explanation-2: -When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen.
There is 1 question to complete.