HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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In which type of epithelial cells are ILC2, TH2, and TH9 cells activated by binding IgE to produce cytokines that recruit, support, and activate mast cells and basophils?
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skin epithelial cells
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intestinal epithelial cells
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -Th2 cytokines, including IL-4 and IL-5, are important mediators in the proliferation and differentiation of B cells and the production of IgA and IgE. Besides, IL-4 activates the transcription factor STAT6 which triggers the development of Th2 cells.
Detailed explanation-2: -Innate lymphoid cells (ILCs) have emerged as an expanding family of effector cells particularly enriched in the mucosal barriers. ILCs are promptly activated by stress signals and multiple epithelial-and myeloid-cell-derived cytokines.
There is 1 question to complete.