HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Lyn-mediated phosphorylation of ITAMs triggers which 2 pathways, leading to allergic effects?
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JAK-STAT
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PKC
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MAPK
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None of the above
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Explanation:
Detailed explanation-1: -The MAPKKKs, which are protein Ser/Thr kinases, are often activated through phosphorylation and/or as a result of their interaction with a small GTP-binding protein of the Ras/Rho family in response to extracellular stimuli.
Detailed explanation-2: -Upon activation by phosphorylation, MAPK proteins dimerize, 5 and can then phosphorylate targets in the cytoplasm, and/or rapidly translocate to the nucleus where they phosphorylate and regulate nuclear target proteins and regulate gene expression.
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