IMMUNOLOGY

Detailed explanation-1: -Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs. A complex interaction of genetics, environment, and hormones leads to immune dysregulation and breakdown of tolerance to self-antigens, resulting in autoantibody production, inflammation, and destruction of end-organs.

Detailed explanation-2: -SLE is a heterogeneous disease influenced by a variety of genetic and environmental factors. Innate and adaptive immune responses contribute to the autoimmune dysfunction observed in SLE. Autoantibodies form immune complexes that drive target organ inflammation in most individuals with SLE.

Detailed explanation-3: -Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by the production of autoantibodies specific for components of the cell nucleus and that causes damage to body tissues and organs.

Detailed explanation-4: -Autoimmune disease occurs when a specific adaptive immune response is mounted against self antigens. The normal consequence of an adaptive immune response against a foreign antigen is the clearance of the antigen from the body.