HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Mast cells express two types of receptors:FcRI (activating) and FcRIIB (inhibiting) Ig receptors. If a cell binds both IgE and IgG, which signal wins? (Hint:this is what makes allergy shots effective)
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IgE
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IgG
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -Fc receptor is a antibody receptor involved in antigen recognition which is located at the membrane of certain immune cells including B lymphocytes, natural killer cells, macrophages, neutrophils, and mast cells. Such receptors recognize Fc fragment of antibodies and that is the name of Fc receptor derived from.
Detailed explanation-2: -The high-affinity receptor for IgE, FcRI, as expressed by mast cells and basophils, consists of an IgE-binding chain, in which the two extracellular domains bind IgE, a chain, which spans the plasma membrane four times and functions as a signal amplifier37, and two identical and largely intracellular chains38.
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