IMMUNOLOGY

Detailed explanation-1: -Nociceptors are sensory receptors that detect signals from damaged tissue or the threat of damage and indirectly also respond to chemicals released from the damaged tissue.

Detailed explanation-2: -Nociceptors have heterogeneous properties, responding to multiple stimulus modalities (polymodal). However, the application of noxious stimulus of one modality may alter the response properties of the nociceptor to other modalities.

Detailed explanation-3: -Most nociceptors respond to noxious mechanical stimuli (painful pressure, squeezing or cutting the tissue), noxious thermal stimuli (heat or extreme cold), and chemical stimuli and are therefore called polymodal. Noxious stimuli evoke a sensory potential in the sensory ending (transduction).