HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following cell-surface receptors is MOST closely linked to activating type I hypersensitivity reactions?
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FcRII
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FcRIIB
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FcRI
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LFA-1
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none of the answers are correct
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Explanation:
Detailed explanation-1: -Type I reactions (i.e., immediate hypersensitivity reactions) involve immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils.
Detailed explanation-2: -Immediate hypersensitivity It is mediated by IgE antibodies, which bind to the surface of mast cells. Within minutes of skin contact by an antigen, the mast cells release histamine and other factors, causing an inflammatory reaction.
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