HYPERSENSITIVITY
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Type I
|
|
|
Type II
|
|
|
Type III
|
|
|
Type IV
|
Detailed explanation-1: -Type I reactions (i.e., immediate hypersensitivity reactions) involve immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils. Examples include anaphylaxis and allergic rhinoconjunctivitis.
Detailed explanation-2: -Anaphylaxis is typically an IgE-mediated (type 1) hypersensitivity reaction that involves the release of numerous chemical mediators from the degranulation of basophils and mast cells after re-exposure to a specific antigen.
Detailed explanation-3: -Key Points. Hypersensitivity reactions to drugs are often type I (immediate, IgE-mediated), but they can be type II, III, or IV.
Detailed explanation-4: -Immediate hypersensitivity (type I) is also known as immediate contact urticaria or contact urticaria syndrome, and the reaction occurs very rapidly. Common causes include insect bites and ingested peanuts. It is mediated by IgE antibodies, which bind to the surface of mast cells.