HYPERSENSITIVITY
CYTOKINES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which chemokine is involved in recruiting neutrophils to the extravascular space during acute inflammation?
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CCL2 (MCP-1)
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CXCL2 (MIP-2)
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CXCL8 (IL-8)
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None of the above
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Explanation:
Detailed explanation-1: -The chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting and activating neutrophils for microbial killing at the tissue site. CXCL1 exists reversibly as monomers and dimers, and mediates its function by binding glycosaminoglycans (GAG) and CXCR2 receptor.
Detailed explanation-2: -Interleukin 8 (IL-8) is a chemotactic factor that attracts neutrophils, basophils, and T-cells during the inflammatory process. It is not a chemotactic factor for monocytes.
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