HYPERSENSITIVITY
CYTOKINES
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
IL-2
|
|
|
IL-3
|
|
|
IL-4
|
|
|
IL-5
|
Detailed explanation-1: -IL-3 stimulates multilineage hematopoietic progenitors (see Table 57-347-50).
Detailed explanation-2: -The IL3 regulates the growth and differentiation of hematopoietic progenitor cells and functionally activates mature neutrophils or macrophages. IL-3 induces MHC class II and B7. 2 expression on eosinophils and renders them capable of supporting T cell proliferation to superantigen and antigen-derived peptides.
Detailed explanation-3: -IL-3 is a pleiotropic hematopoietic cytokine supporting the proliferation and differentiation of both primitive multipotent progenitor cells and committed myeloid progenitors.
Detailed explanation-4: -IL-12 is a Th1 cytokine that is predominantly generated by cells in the innate immune system. Its role is associated with the differentiation of naïve T cells into Th1 cells. In allergy, IL-12 is known to downregulate allergic inflammation following its release, along with IFN.