HYPERSENSITIVITY
IMMUNO TOLERANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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FOXP3
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CD3
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CD8
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IgM
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Detailed explanation-1: -CNS2 demethylation stabilizes FoxP3 expression and is characteristic of tTregs (43–45). Attempts are under way to artificially stabilize FoxP3 expression in in vitro induced Tregs for further clinical application (46).
Detailed explanation-2: -Treg cells are characterized by the expression of canonical markers that are common regardless of their origin. In secondary lymphoid organs, Treg cells are characterized by high expression of Foxp3, CD25, GITR, Nrp1, Helios, and CTLA-4 as compared to conventional CD4 T cells (Figure 7.2a and b).
Detailed explanation-3: -In conclusions, Foxp3 is a good marker of Tregs especially if panels of markers were used for their identification. CD4(+)CD25(high) Foxp3(+) T cell subpopulation mostly represents Tregs and thus should be the one targeted in Treg studies.