HYPERSENSITIVITY
IMMUNO TOLERANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What does CD8+ normally attaches to, to provide the primary signal for cytotoxic T-cells to activate?
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MHCI
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MHCII
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TCR
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BCR
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Explanation:
Detailed explanation-1: -Naïve CD8 T cells become activated when they recognize peptide antigen bound to MHC I at the surface of bone marrow–derived pAPCs.
Detailed explanation-2: -The CD8 co-receptor binds to a largely invariant region of MHCI that is spatially distinct from the TCR binding platform, allowing the potential for tripartite (TCR–pMHCI–CD8) complex formation (Fig. 1).
Detailed explanation-3: -Cytotoxic CD8 T cells carry out their killing function by releasing two types of preformed cytotoxic protein: the granzymes, which seem able to induce apoptosis in any type of target cell, and the pore-forming protein perforin, which punches holes in the target-cell membrane through which the granzymes can enter.
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