IMMUNOGLOBULINS
COMPLEMENT SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Certain microorganisms such as Salmonella, Listeria, Neisseria, Cryptococcus consist of specific carbohydrate moieties on the surface antigen that activate ____
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Alternative Pathway
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Classical Pathway
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Lectin Binding Pathway
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All of the above
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Explanation:
Detailed explanation-1: -The lectin pathway of the complement is activated when MBL binds to hexoses with carbon 3 and 4 OH groups such as N-acetyl-d-glucosamine, glucose, fucose, and mannose. These sugars are expressed as repetitive O-polysaccharide structures on surfaces of bacteria, yeast, parasites, mycobacteria, and certain viruses.
Detailed explanation-2: -Only IgM and the IgG subclasses, IgG1 and IgG3, can produce strong complement responses. The classical complement pathway is activated when IgG or IgM is bound to its target antigen on either the pathogen cell membrane or an immune complex.
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