IMMUNOGLOBULINS
COMPLEMENT SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Alternative pathway
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Classical pathway
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Lectin binding pathway
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None of the above
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Detailed explanation-1: -C2 deficiency is associated with an increased risk of infections with encapsulated bacteria, such as Haemophilus influenzae.
Detailed explanation-2: -Autoimmunity – The most common autoimmune disorder by far among patients with a total complement deficiency is SLE [6-18]. SLE commonly develops in individuals deficient in an early component of the classical pathway (ie, C1q, C1r, C1s, C4, and C2).
Detailed explanation-3: -Deficiencies of early components of the classical complement pathway, including C1, C4, and C2, are associated with encapsulated bacterial infections like Streptococcus Pneumoniae and Haemophilus Influenza type b. [7] A deficiency of C3 is associated with severe recurrent pyogenic infections early in life.