IMMUNOGLOBULINS
COMPLEMENT SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What makes the classical complement pathway a part of both the innate and adaptive immune response?
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It includes lectins and ficolins
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It includes antibodies and C1 complex
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It gets stronger with each additional exposure to the target
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It is slow
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Explanation:
Detailed explanation-1: -The classical pathway plays a role in both innate and adaptive immunity. As we will see in Chapter 9, the first component of this pathway, C1q, links the adaptive humoral immune response to the complement system by binding to antibodies complexed with antigens.
Detailed explanation-2: -The function of complement in innate host defense is accomplished through three broad effector pathways; lysis, inflammation, and opsonization/phagocytosis.
Detailed explanation-3: -It is well known that both IgG and IgM can activate complement via the classical pathway by binding of C1q to the Fc regions of these immunoglobulins. Recent advances have shown that also IgA is capable of activating the complement system.
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