IMMUNOGLOBULINS
MONOCLONAL ANTIBODIES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Khorana and Nirenberg
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Khorana and Korenberg
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Kohler and Milstein
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Beedle and Tautum
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Detailed explanation-1: -Köhler and César Milstein described the hybridoma technique for production of monoclonal antibodies. They immortalized antibody producing cells by fusing them with tumour cells. The method allows unlimited production of monoclonal antibodies with predetermined specificity.
Detailed explanation-2: -In 1975, Georges Kohler and Cesar Milstein succeeded in making fusions of myeloma cell lines with B cells to produce hybridomas that made antibodies to known antigens. Monoclonal antibodies were first produced by applying the techniques of somatic cell genetics to antibody-producing cells.
Detailed explanation-3: -The invention of monoclonal antibody (mAb) technology provided scientists with a tool to pursue that dream. In 1975, researchers César Milstein and Georges Köhler, working at the Laboratory for Molecular Biology in England, developed a technique for creating cells that could pump out streams of identical antibodies.