IMMUNOLOGY

Detailed explanation-1: -Hybridoma technology is one of the most common methods used to produce monoclonal antibodies. In this process, antibody-producing B lymphocytes are isolated from mice after immunizing the mice with specific antigen and are fused with immortal myeloma cell lines to form hybrid cells, called hybridoma cell lines.

Detailed explanation-2: -The myeloma cells cannot produce antibody, but they will grow in culture. The two cells (spleen cells and myeloma cells) are fused together to produce a hybrid cell (hybridoma) that has the best properties of both cells – the hybridoma grows in culture and makes antibody.