IMMUNOLOGY

Detailed explanation-1: -A small example is, if the mice were injected with a certain virus, the mouse will have B-Lymphocytes that produce those specific virual antibodies. Fusion with a tumor cell to make the hybridoma, result in the production of monoclonal antibodies against the specific virus.

Detailed explanation-2: -Some types of cancerous cells have specific antigens on their surface called tumour markers . Monoclonal antibodies can be produced to bind specifically with these antigens. When injected into a person’s body, the monoclonal antibodies will bind with these cancer cells and clump them together.

Detailed explanation-3: -The traditional monoclonal antibody (mAb) production process usually starts with generation of mAb-producing cells (i.e. hybridomas) by fusing myeloma cells with desired antibody-producing splenocytes (e.g. B cells). These B cells are typically sourced from animals, usually mice.