IMMUNOLOGY

IMMUNOGLOBULINS

MONOCLONAL ANTIBODIES

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why are mice injected with antigens?
A
so they produce lymphocytes with the specific antibody.
B
so they produce lymphocytes with the specific antigen.
C
so they produce tumour cells.
D
so they produce clone cells.
Explanation: 

Detailed explanation-1: -A The Source of Antibody-Secreting Lymphocytes. In generating murine hybridomas, the spleen of an immunized mouse is used as a source of the mixed lymphocyte population for cell selection. Clearly this is not possible with humans and the source of human lymphocytes is limited to samples of peripheral blood.

Detailed explanation-2: -We shall see that each lymphocyte is committed to respond to a specific antigen and that its response during its first encounter with an antigen ensures that a more rapid and effective response occurs on subsequent encounters with the same antigen.

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