OVERVIEW OF THE IMMUNE SYSTEM
IMMUNITY INNATE AND ADAPTIVE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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1, 3, 2, 4
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2, 3, 1, 4
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1, 3, 4, 2
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1, 4, 3, 2
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Detailed explanation-1: -B cells are activated when they encounter an antigen that they recognize. The antigen binds to the B cell’s surface receptors, which activates and triggers it to divide and differentiate into an antibody-secreting plasma cell. Plasma cells produce antibodies that bind to the antigen and neutralize it.
Detailed explanation-2: -During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage.
Detailed explanation-3: -B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).
Detailed explanation-4: -A B cell becomes activated when its receptor recognizes an antigen and binds to it. Most antigens are T-dependent. Interaction with antigens causes B cells to multiply into clones of immunoglobulin-secreting cells. The process just described takes place among the circulating B lymphocytes.