OVERVIEW OF THE IMMUNE SYSTEM
LYMPHOCYTE SUBPOPULATION IN HUMANS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Lipase
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Protease
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Granzymes
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Amylase
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Detailed explanation-1: -Cytotoxic CD8 T cells carry out their killing function by releasing two types of preformed cytotoxic protein: the granzymes, which seem able to induce apoptosis in any type of target cell, and the pore-forming protein perforin, which punches holes in the target-cell membrane through which the granzymes can enter.
Detailed explanation-2: -Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells.
Detailed explanation-3: -Granzymes are a family of serine proteases traditionally known for their role in promoting cytotoxicity of foreign, infected or neoplastic cells. Granzymes induce (apoptotic) cell death mediated by a collective of cytotoxic lymphocytes (CLs) (e.g. cytotoxic T lymphocytes (CTLs), natural killer (NK) cells).