IMMUNOLOGY

Detailed explanation-1: -The first step in phagocytosis is the detection of the particle by phagocytes. This, as mentioned before, is accomplished by specialized receptors on the cell membrane.

Detailed explanation-2: -Chemotaxis is the directional movement of the phagocyte towards a chemical attractant (chemotaxins). Chemotaxins include bacterial products (e.g. endotoxin), injured tissues, complement proteins (C3a, C4a, C5a) and chemical substances produced by leukocytes (leukotrienes).

Detailed explanation-3: -On the one hand, classical chemotaxis is the directed movement of cells along a concentration gradient of soluble chemicals emanating from a distant source (Box 2). Phagocytosis, on the other hand, is the enveloping motion by which cells engulf and internalize particles (Fig. 1A, B; Box 2).

Detailed explanation-4: -Step 1: Activation of the Phagocyte. Step 2: Chemotaxis of Phagocytes (for wandering macrophages, neutrophils, and eosinophils) Step 3: Attachment of the Phagocyte to the Microbe or Cell. Step 4: Ingestion of the Microbe or Cell by the Phagocyte. 09-Apr-2022