OVERVIEW OF THE IMMUNE SYSTEM
THE GOOD BAD AND UGLY OF THE IMMUNE SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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B cells
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T cells
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Helper T cells
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Macrophages
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Detailed explanation-1: -HIV contains a glycoprotein called gp120 that binds onto a glycoprotein called CD4 found on helper T-cells. It then uses another glycoprotein called gp41 to initiate cell-mediated endocytosis. This fuses the viral and cell membrane and brings the viral contents into the cell.
Detailed explanation-2: -HIV binds to the CD4 molecule on the surface of helper T-cells and replicates within them. This results in destruction of CD4+ T-cells and leads to a steady decline in this population of T-cells.
Detailed explanation-3: -To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor.
Detailed explanation-4: -Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection.
Detailed explanation-5: -HIV primarily targets a type of cell in the immune system called the CD4+ T cell.