IMMUNOLOGY

Detailed explanation-1: -The spleen is a small organ inside your left rib cage, just above the stomach. It’s part of the lymphatic system (which is part of the immune system). The spleen stores and filters blood and makes white blood cells that protect you from infection.

Detailed explanation-2: -Organs and tissues important to the proper functioning of the immune system include the thymus and bone marrow, lymph nodes and vessels, spleen, and skin.

Detailed explanation-3: -Primary lymphoid organs: These organs include the bone marrow and the thymus. They create special immune system cells called lymphocytes. Secondary lymphoid organs: These organs include the lymph nodes, the spleen, the tonsils and certain tissue in various mucous membrane layers in the body (for instance in the bowel).

Detailed explanation-4: -The spleen is a reservoir of different immune cells, some with anti-tumor immunity like T cells, B cells, NK cells, and macrophages.

Detailed explanation-5: -The spleen is a site of immune tolerance induction The spleen’s tolerogenic role depends on MZ cellular interactions between different macrophage subsets, CD8+ DCs, pDCs, inflammatory Ly6Chi monocytes, NKT cells, TNF-related apoptosis inducing ligand (TRAIL)+ CD8+ T cells and CD4+Foxp3+ Tregs.