MICROANATOMY

Detailed explanation-1: -With the continued migration of osteoblasts and osteoclasts, the hard callus undergoes repeated remodeling-termed ‘coupled remodeling.’ This ‘coupled remodeling’ is a balance of resorption by osteoclasts and new bone formation by osteoblasts.

Detailed explanation-2: -First, inflammation occurs after the injury. Then the bone is induced to repair and is forming soft callus. At the third step the bone gets stronger and forms hard callus. At the last step, the new compact bone is formed and blood vessels regenerate.

Detailed explanation-3: -The remodeling stage starts around 6 weeks after the injury. In this stage, regular bone replaces the hard callus. If you saw an X-ray of the healing bone, it would look uneven. But over the next few months, the bone is reshaped so that it goes back to looking the way it did before the injury.

Detailed explanation-4: -ACTIVATION, RESORPTION, REVERSAL, FORMATION, and QUIESCENCE. The total process takes about 4 to 8 months, and occurs continually throughout our lives.

Detailed explanation-5: -The remodelling cycle occurs within the basic multicellular unit and comprises five co-ordinated steps; activation, resorption, reversal, formation and termination. These steps occur simultaneously but asynchronously at multiple different locations within the skeleton.