RESEARCH METHODOLOGY

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INTRODUCTION

RESEARCH AND SCIENTIFIC METHODS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In Texas, researchers gave a cholesterol-reducing drug to 2, 335 people and an inactive substitute (placebo) to 2, 081. Most of the volunteers were men who had normal cholesterol levels and no history of heart disease. After 5 years, 97 people getting the placebo had suffered heart attacks compared to only 57 people who had received the actual drug. The researchers are recommending that to help prevent heart attacks, all people (even those without high cholesterol) takes these cholesterol-reducing drugs. In addition to the information above, what is another piece of information that the researchers must have before support for the recommendation can be justified?
A
A-Were eating habits of the two groups similar?
B
B-How does a heart attack affect cholesterol levels?
C
C-Did the heart attacks result in deaths?
D
D-What chemical is in the placebo?
Explanation: 

Detailed explanation-1: -Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes. You take a tablet once a day.

Detailed explanation-2: -Statins-Statins are one of the best-studied classes of medications and the most commonly used drugs for lowering LDL cholesterol. They are the most effective drugs for prevention of coronary heart disease, heart attack, stroke, and death.

Detailed explanation-3: -Lovastatin belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. It works to reduce the amount of cholesterol in the blood by blocking an enzyme that is needed by the body to make cholesterol.

Detailed explanation-4: -There are currently seven HMG-CoA reductase inhibitors (statins) approved for lowering cholesterol levels and they are the first line drugs for treating lipid disorders and can lower LDL-C levels by as much as 60%. Statins also are effective in reducing triglyceride levels in patients with hypertriglyceridemia.

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