IMMUNE RESPONSE
CLASSICAL ALTERNATE AND LECTIN PATHWAYS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Thyroid
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Spleen
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Bone
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Lymph Nodes
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Detailed explanation-1: -In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricius, a lymphoid organ where they were first discovered by Chang and Glick, which is why the ‘B’ stands for bursa and not bone marrow as commonly believed.
Detailed explanation-2: -In addition to this immune function, B cells have a close and multifaceted relationship with bone cells. B cells differentiate from hematopoietic stem cells (HSCs) in supportive niches found on endosteal bone surfaces.
Detailed explanation-3: -B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).