IMMUNOGLOBULINS
IMMUNOGLOBULIN STRUCTURE TYPES DISTRIBUTION BIOLOGICAL AND CHEMICAL PROPERTIES
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Question
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IgM and IgA
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IgM and IgD
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IgG and IgE
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IgG and IgD
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Detailed explanation-1: -Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually co-expressed with another cell surface antibody called IgM.
Detailed explanation-2: -IgD is uniquely co-expressed with IgM during a narrow developmental window on late transitional and mature naïve Fo B cells as a result of alternate splicing regulated by the zinc-finger protein ZFP318 (Enders et al., 2014; Pioli et al., 2014).
Detailed explanation-3: -Prior to mounting an immune response, B cells carry two closely related versions of the B cell receptor on their surface: IgM and IgD. Both IgM and IgD perform many of the same roles and can largely substitute for one another.