OVERVIEW OF THE IMMUNE SYSTEM
LYMPHOCYTE SUBPOPULATION IN HUMANS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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True
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False
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Either A or B
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None of the above
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Detailed explanation-1: -Positively selected T cells then go through negative selection: T cells binding self-peptide–HLA complexes with high affinity are deleted from the repertoire, referred to as central tolerance (6).
Detailed explanation-2: -(Developing T cells are positively selected for their ability to bind MHC as well as peptide.) Negative selection means that binding to the receptor results in cell death. Both immature B and T cells are negatively selected if they bind self antigen.
Detailed explanation-3: -In the thymus, T cells develop their specific T cell markers, including TCR, CD3, CD4 or CD8, and CD2. T cells also undergo thymic education through positive and negative selection. The thymus is a multi-lobed organ composed of cortical and medullary areas surrounded by a capsule.